Giant cell tumor (GCT), also known as osteoclastoma, is a rare neoplasm characterized by the proliferation of osteoclast-type multinucleated giant cells. It is a generally benign but locally aggressive neoplasm characterized by a proliferation of mononuclear stromal cells and numerous osteoclast-like giant cells.
Giant cell tumors (GCTs) of the uterus rarely encountered in gynecologic malignancies and may pose substantial diagnostic challenges. While traditionally regarded as a benign tumor, GCT of the uterus may demonstrate a benign or malignant behavior and, in rare instances, pose significant diagnostic and therapeutic challenges.
This is a case of 50-year-old woman who presented with post menopausal bleeding managed initially as a malignant carcinosarcoma and underwent exploratory laparotomy with peritoneal cytology, extrafascial hysterectomy with bilateral salpingo-oophorectomy, infracolic omentectomy, and bilateral pelvic lymph node dissection and chemotherapy but on extensive pathologic review, belonged to the less than 0.1% of a rare case of a benign pure giant cell tumor of the uterus.